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Upload and storage of complex in vivo data

Product: gritInVivo

In the IMI COMBINE project our grit42 platform is used as the central scientific data management tool storing both compounds as well as in vitro, in vivo and the clinical data for the long term, in the same place, with aligned meta data enabling cross study analysis.

The in vivo study data are from fairly complex multi group studies with both pre-treatments, complex dosing schedules and sample collection. Virulence experiments have been performed in order to define what bacteria and strain to use and for how long to enable relevant compound test experiments. 

Following the virulence studies "compound testing" experiments are being performed. All the animal level data - from both kinds of in vivo studies - including the study design information are being uploaded to the grit data store.

new study simple - groups


Complex multi-group studies

The IMI COMBINE data management project team has developed FAIR data templates to ensure structured and aligned data collection across the data producers.

All the complex in vivo data are collected by the in vivo lab and delivered to Fraunhofer via the COMBINE data template. Fraunhofer performs a QC check of the data and loads them into grit linked to the relevant compounds, bacterias etc.

Future use: Study planning and in life execution

Together with the in vivo lab in question we are now exploring an extension of the reach of the data platform and data workflows.

The in vivo lab will in the future utilise the grit42 tools for both the study planning and in life execution of their IMI COMBINE studies after which the relevant data can be exported and delivered to Fraunhofer for the long term storage.