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A virtual laboratory CRO supported antibody drug discovery

Product: grit

For one of the largest charitable foundations in the world, we’ve created a streamlined data management and analysis setup, handling a multitude of different types of data, coming from multiple Contract Research Organisations (CROs).

The drug discovery unit is - in this case - a fully virtual lab.  Or in other words, they only have offices! All lab work is therefore performed by a mix of CROs and academic labs with different levels of maturity regarding data management.

Several "compound providers" produced and delivered the antibodies which was then distributed to several labs for in vitro and in vivo characterisations demanding a high level of structure and ID management in the process. 

virtual-ddnov2021

All data are registered, cleaned, and FAIRified

The data on the compounds – in this case antibodies – are received from several suppliers and uploaded into the grit42 platform including their respective origin and an origin compound ID.

Once the individual assays datasets are received from several different partners – both academic labs and CROs in this case – they are registered, cleaned, FAIRified, and set up on the platform. These types of assays range from simple in vitro screening assays, over more complex functional assays, to DMPK and in vivo mouse studies.

SAR tables are created to analyse the data and compare the pharmacological profiles across the assay data and make informed progression decisions. The SAR tables from grit42’s platform also have the ability to plot assay versus assay in order to compare and analyse correlations across the different datasets.

Comparisons and analyses across multiple data partners

In other words, grit42’s platform ensures that all the data – no matter where it’s coming from – is labeled and registered in a coherent and FAIR fashion, enabling comparisons and analyses across the multiple data delivery partners.